The serum which Dr Curtis Connors used to regenerate his missing right arm also had an unintended side effect. While transformed into The Lizard, Connors possesses a variety of superhuman attributes.
Superhuman Strength: Connors himself has the normal physical strength of a human male of his age, height, and build that engages in little regular exercise. While transformed, he possesses sufficient superhuman strength. He can overpower normal humans, turn over standard vehicles such as cars and vans and even Spider-Man who himself is stronger than normal humans as well. His physical strength has extended into the muscles of his legs allowing him to leap great distances.
Superhuman Speed: While transformed, Connors can run and move at speeds greater than that of the finest human athlete and can reach a top speed of about 45 miles per hour. He is shown to be slightly faster than Spider-Man himself.
Superhuman Stamina: While transformed, Connors' advanced musculature produces considerably less fatigue toxins during physical activity than the musculature of an ordinary human. He can physically exert himself at peak capacity for about 24 hours before fatigue begins to impair him.
Superhuman Durability: While transformed, Connors' scaly skin and superhumanly enhanced bodily tissues provide him much greater resistance to physical injury than an ordinary human. He can withstand great impact forces, falls from great heights, and small caliber bullets without sustaining injury.
Superhuman Agility: In his transformed state, Connors' agility, balance, and bodily coordination are enhanced to levels that are beyond the natural physical limits of even the finest human athlete. His agility rivals Spider-Man.
Superhuman Reflexes: Connors' reflexes are similarly enhanced while transformed and are superior to those of the finest human athlete.
Regenerative Healing Factor: Despite The Lizard's physical durability, he can sustain physical injury. However, if injured, his body is able to rapidly regenerate damaged or destroyed tissue with much greater speed and efficiency than an ordinary human. While transformed, Connors' healing powers are developed to the point where he can fully regenerate missing limbs, just like many known reptile species.
Tail: While transformed, Connors has a long, reptilian-like tail that he can use to help balance himself or as an offensive weapon. He is capable of whipping his tail at speeds of at least 70 miles per hour. Considering his strength and physical toughness, he can generate enough force to shatter concrete. He can also use it to strangle people with it. He was also seen actually detaching his tail in order to get Spider-Man off him; however with his regenerative capabilities; he grew a new one afterwards.
Fangs & Claws: While transformed, Connors' fingers and toes are each tipped with razor sharp claws that, combined with his natural strength, are able to cut most conventional materials including flesh, bone, wood, stone, and some types of metals. He can punch through the roof of a car and can tear through metal objects like lockers and other stuff. His mouth is also filled with rows of razor sharp teeth that he can use as offensive weapons in close combat situations.
Psionics: The Lizard has a limited ability to command or attract reptlies to him. It is unknown if he is able to control it or not. This could also be the result of a kind of pheromone the Lizard may produce. Abilities Connors has a genius-level intelligence and is an expert in reptiles as well. Although he has had no formal combat training, his powers alone coupled with his natural savagery in his transformed state make him a formidable combatant. In this form, he can talk and is still intelligent albeit twisted.
